Thera Signal

Resources

How the grading, regulatory language, and ingestion pipeline actually work — so a badge or score on this site is never a black box.

How grading works

Every scientific claim is tagged with an evidence class at extraction time, from Class A (the strongest human evidence) down to Class F (public chatter, tracked separately from the Real-World corpus). A compound's Science Strength score is derived from how many claims it has and their class mix — never a fabricated number, and always "no published science indexed yet" rather than a fake low score when nothing has been ingested.

A
Controlled human trial
Randomized or otherwise controlled study in humans.
B
Observational / registered trial
ClinicalTrials.gov registrations and observational human studies.
C
Preclinical
Animal or in-vitro studies — mechanism evidence, not human outcome evidence.
D
Clinic cohort
Real-world outcomes from a clinical practice, not a formal trial.
E
High-confidence public report
A detailed, source-integrity-scored first-person account.
F
Public chatter
Lower-confidence social mentions — useful as signal, not as evidence.

Regulatory status glossary

Nearly every compound tracked here carries some form of regulatory caution — that's expected, not a red flag unique to one compound. Here's what the language on each compound's Regulatory tab actually means.

Unapproved drug
No FDA approval exists for this substance in any form or indication — the default status for nearly everything tracked here.
503A Bulks List
FDA's list of substances compounding pharmacies may legally use — nomination and review is an ongoing, public process, not a one-time decision.
Compounding warning
FDA guidance flagging insufficient safety/efficacy data for a substance pharmacies are compounding anyway.
Drug enforcement recall
An active FDA enforcement action — typically a sterility, contamination, or labeling failure at a specific manufacturer.
Research Use Only
Vendor-facing label meaning "not for human consumption" — a legal fiction the regulatory record tracks regardless of how it is actually used.

How ingestion & sourcing works

Every claim and report traces back to an immutable source document — PubMed and ClinicalTrials.gov feed the Science corpus; Reddit, YouTube comments, and X feed Real-World reports; YouTube video transcripts feed the Video corpus, chunked and timestamp-linked so a citation jumps to the exact moment. A language model does the extraction (dose, outcome, adverse event, indication), with a deterministic fallback extractor if that call fails — nothing is silently dropped. Reddit and YouTube publish automatically; newer sources like X hold for a human review pass before appearing publicly.

Reconstitution calculator guide

Enter the total amount in the vial and how much bacteriostatic/sterile water you added — that gives a concentration (mg per mL). Enter a target dose and the calculator works backward to the exact draw volume, in both mL and insulin-syringe units (U-100). The multi-blend mode splits a target dose proportionally across every ingredient by its share of the vial's total mass.

Open the calculator

Vendor directory

How the peptide supply market breaks down into manufacturers, research-chemical sites, and licensed 503A compounding pharmacies — plus a live, classified directory of vendors cross-checked against real community sentiment.

Open the vendor directory